IFR 128 BioSciences Gerland - Lyon Sud

U851 INSERM – UCBL – HCL

 

Team: APOPTOSIS and CD8 T cells MEMORY

Team leader: Jacqueline Marvel

 

Current project

Related Project

Team members

Publications

Thesis

Open position

 

 

Deniaud E, Baguet J, Chalard R, Blanquier B, Brinza L, Meunier J, Michallet MC, Laugraud A, Ah-Soon C, Wierinckx A, Castellazzi M, Lachuer J, Gautier C, Marvel J, Leverrier Y.
Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition.
PLoS One. 2009 Sep 15;4(9):e7035.

Mbitikon-Kobo FM, Vocanson M, Michallet MC, Tomkowiak M, Cottalorda A, Angelov GS, Coupet CA, Djebali S, Marçais A, Dubois B, Bonnefoy-Bérard N, Nicolas JF, Arpin C, Marvel J.

Characterization of a CD44/CD122int memory CD8 T cell subset generated under sterile inflammatory conditions

J Immunol. 2009 Mar 15;182(6):3846-5

Mercier BC, Cottalorda A, Coupet CA, Marvel J, Bonnefoy-Bérard N.

TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal.

Journal of Immunology 2009 Feb 15;182(4):1860-7.

Grégoire C, Cognet C, Chasson L, Coupet CA, Dalod M, Reboldi A, Marvel J, Sallusto F, Vivier E, Walzer T.

Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation.

European Journal of Immunology 2008 Aug;38(8):2076-84.

Dong W., Arpin C., Accardi R., Gissmann L., Sylla B.S., Marvel J. and Tommasino M.

Loss of p53 or p73 in human papillomavirus type 38 E6 and E7 transgenic mice partially restores the UV-activated cell cycle checkpoints

Oncogene 2008 May 1;27(20):2923-8.

Marçais A., Tomkowiak M., Walzer T., Coupet C.-A., Ravel-Chapuis A.  and Marvel J.

Maintenance of CCL5 mRNA stores by memory CD8 T cells is dependent on transcription and is coupled to increased mRNA stability.

European Journal of Immunology. (2006) Oct;36(10):2745-54

Deniaud E, Baguet J., Mathieu A-L, Page G, Marvel J and Leverrier Y.

Overexpression of Sp1 transcription factor induces apoptosis

Oncogene 2006, May 22, 1–10

Cottalorda A., Verschelde C., Marçais A., Tomkowiak M., Musette P., Uematsu S., Akira S., Marvel J. , Bonnefoy-Berard N.

TLR2 engagement on CD8+ T cells lowers thresholh for optimal antigen-induced T cell proliferation.

European Journal of Immunology 2006 Jul; 36(7):1684-93.

Marçais A., Coupet C.-A.,, Walzer T., Tomkowiak M., Ghittoni R., and Marvel J.

Cell-autonomous CCL5 transcription by memory CD8 T cells is regulated by IL-4

Journal of Immunology 2006 Oct 1;177(7):4451-7.

Angelov GS, Tomkowiak M, Marçais A, Leverrier Y and  Marvel J. 

Flt3 ligand generated murine plasmacytoid and myeloid dendritic cells differ in their capacity to prime naive CD8+ T cells and to generate memory cells in vivo

Journal of Immunology 2005, 175(1):189-95.

Quéméneur L., Beloeil L, Michallet M.C., Angelov G., Tomkowiak M., Revillard J.P. and Marvel J.
Restriction of de novo nucleotide biosynthesis interferes with clonal expansion and differentiation into effector and memory CD8 T cells
Journal of Immunology 2004, 173: 4945–4952

T. Walzer, A. Marçais, F. Saltel, C.Bella, P. Jurdic and J. Marvel
Immediate RANTES secretion by resting memory CD8 T cells following antigenic stimulation
Journal of Immunology 2003, 170: 1615-1619

L. Beloeil, M. Tomkowiak, G. Angelov, T. Walzer, P. Dubois and J. Marvel
In vivo impact of CpG1826 ODN on CD8 T cell primary responses and survival
Journal of Immunology 2003; 4:1615-9.

C. Arpin, G. Angelov, T. Walzer, M. Tomkowiak, L. Beloeil, and J. Marvel
Hyperproliferative Response of a Monoclonal Memory CD8 T Cell Population Is Characterized by an Increased Frequency of Clonogenic Precursors
Journal of Immunology 2002, 168: 2147-2153.

T. Walzer, C. Arpin, L. Beloeil, and J. Marvel
Differential In Vivo Persistence of Two Subsets of MemoryPhenotype CD8 T Cells Defined by CD44 and CD122 Expression Levels
J.Immunol., 2002., 15;168(6):2704-11

S. Gonin-Giraud, A.L. Mathieu, S. Diockou, M. Tomkowiak, G. Delorme and J. Marvel.
Decreased glycolytic metabolism contributes to but is not the inducer of apoptosis following IL-3-starvation
Cell Death and Differentiation 2002, vol 9 (10) : 1140-1147

A.L. Mathieu, S. Gonin, Y. Leverrier, B. Blanquier, J. Thomas, C. Dantin, G. Martin, G. Baverel and J. Marvel.
Activation of the PI3-kinase/Akt pathway protects against IL-3-starvation but not DNA damage-induced apoptosis
Journal of Biological Chemistry 2001,vol 276 (14) : 10935-42

S. Ugolini, C. Arpin, N. Anfossi, T. Walzer, A. Cambiaggi, R. Förster, M. Lipp, R. E. M. Toes, C.J. Melief, J. Marvel and E. Vivier
Involvement of inhibitory NRKs in the survival of Tm1 cells, a NKR+ subset of memory CD8+ T cells
Nature Immunology 2001 vol 2 (5) : 430-5

Reviews :

Thomas J., Leverrier Y., Mathieu A-L and Marvel J..

Identification of apoptosis regulatory genes using insertional mutagenesis

Methods in molecular biology, 2004, vol 282 : 275-89

Bonnefoy-Berard N, Aoucheria A, Verschelde C, Quemeneur L, Marçais A, Marvel J.

Control of proliferation by Bcl-2 family members

Biochimica et Biophysica Acta , 1644 ,2004, 159-168.