| IFR128
BioSciences Gerland - Lyon Sud |
| U851
INSERM-UCBL "Immunité, Infection, Vaccination" |
| Recherche
de cibles et de molécules thérapeutiques. Métabolisme, virus et immunité. |
|
| Responsables
d'équipe :
|
|
|
ANDRE Patrice |
patrice.andre@inserm.fr |
| LOTTEAU Vincent | vincent.lotteau@inserm.fr |
| Adresse : | ||
| INSERM U851 | Téléphone
: |
04 37 28 23 40 |
| 21, Avenue Tony Garnier |
Fax
: |
04 37 28 23 41 |
| 69365 Lyon Cedex 07 | ||
| Affiliation : INSERM – Université Claude Bernard Lyon I | ||
| Membres de l’équipe : | |
| Direction | |
| Vincent LOTTEAU | DR INSERM |
| Patrice ANDRE | PUPH HCL |
| Laure PERRIN-COCON | CR INSERM |
| Olivier DIAZ | MCU UCBL |
| Martine CARRERAS | TCS INSERM |
| Sandra DOLLET | IE CDD |
| Christophe RAMIERE | Doctorant 2eme Année |
| Amandine VERGA-GERARD | Doctorante 1ere Année |
| Claire CURTIL | Etudiante Master 2 |
| Principales Publications : |
Icard
V, Diaz O, Scholtes C, Perrin-Cocon L, Ramière C, Bartenschlager
R, Penin F, Lotteau V, André P. Secretion of Hepatitis C Virus Envelope Glycoproteins Depends on Assembly of Apolipoprotein B Positive Lipoproteins. PLoS ONE. 2009 4(1): e4233. |
Navratil
V, de Chassey B, Meyniel L, Delmotte S, Gautier C, André P, Lotteau
V, Rabourdin-Combe C. VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks. Nucleic Acids Res. 2009 Jan;37(Database issue):D661-8. Epub 2008 Nov 4. De Chassey, B., Navratil V., Tafforeau L., Hiet M. S., Aublin-Gex A., Agaugue S., Meiffren G., Pradezynski F., Faria B. F., Chantier T., Le Breton M., Pellet J., Davoust N., Mangeot P. E., Chaboud A., Penin F., Jacob Y., Vidalain P. O., Vidal M., Andre P., Rabourdin-Combe C., and Lotteau V. Hepatitis C virus infection protein network. Mol Syst Biol. 2008; 4:230. Perrin-Cocon L, Agaugué S, Diaz O, Vanbervliet B, Dollet S, Guironnet-Paquet A, André P, Lotteau V. Th1 disabled function in response to TLR4 stimulation of monocyte-derived DC from patients chronically-infected by hepatitis C virus. PLoS ONE. 2008 May 28;3(5):e2260. Ramière C, Scholtès C, Diaz O, Icard V, Perrin-Cocon L, Trabaud MA, Lotteau V, André P. Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha. J Virol. 2008 Nov;82(21):10832-40. Diaz O, Cubero M, Trabaud MA, Quer J, Icard V, Esteban JI, Lotteau V, André P. Transmission of low-density hepatitis C viral particles during sexually transmitted acute resolving infection. J Med Virol. 2008 Feb;80(2):242-6. Scholtes C, Diaz O, Icard V, Kaul A, Bartenschlager R, Lotteau V, André P. Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR. J Hepatol. 2008 Feb;48(2):192-9. Agaugué S, Perrin-Cocon L, André P, Lotteau V. Hepatitis C lipo-Viro-particle from chronically infected patients interferes with TLR4 signaling in dendritic cell. PLoS ONE. 2007 Mar 28;2(3):e330. Diaz O, Delers F, Maynard M, Demignot S, Zoulim F, Chambaz J, Trépo C, Lotteau V, André P. Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteins. J Gen Virol. 2006 Oct;87(Pt 10):2983-91. Agaugué S, Perrin-Cocon L, Coutant F, André P, Lotteau V. 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. J Immunol. 2006 Aug 15;177(4):2061-71. Perrin-Cocon L, Agaugué S, Coutant F, Saint-Mézard P, Guironnet-Paquet A, Nicolas JF, André P, Lotteau V. Lysophosphatidylcholine is a natural adjuvant that initiates cellular immune responses. Vaccine. 2006 Feb 27;24(9):1254-63. André P, Perlemuter G, Budkowska A, Bréchot C, Lotteau V. Hepatitis C virus particles and lipoprotein metabolism. Semin Liver Dis. 2005 Feb;25(1):93-104. Review. Deforges S, Evlashev A, Perret M, Sodoyer M, Pouzol S, Scoazec JY, Bonnaud B, Diaz O, Paranhos-Baccalà G, Lotteau V, André P. Expression of hepatitis C virus proteins in epithelial intestinal cells in vivo. J Gen Virol. 2004 Sep;85(Pt 9):2515-23. Perrin-Cocon L, Agaugué S, Coutant F, Masurel A, Bezzine S, Lambeau G, André P, Lotteau V. Secretory phospholipase A2 induces dendritic cell maturation. Eur J Immunol. 2004 Aug;34(8):2293-302. Komurian-Pradel F, Perret M, Deiman B, Sodoyer M, Lotteau V, Paranhos-Baccalà G, André P. Strand specific quantitative real-time PCR to study replication of hepatitis C virus genome. J Virol Methods. 2004 Mar 1;116(1):103-6. Coutant F, Agaugué S, Perrin-Cocon L, André P, Lotteau V. Sensing environmental lipids by dendritic cell modulates its function. J Immunol. 2004 Jan 1;172(1):54-60. Coutant F, Perrin-Cocon L, Agaugué S, Delair T, André P, Lotteau V. Mature dendritic cell generation promoted by lysophosphatidylcholine. J Immunol. 2002 Aug 15;169(4):1688-95. André P, Komurian-Pradel F, Deforges S, Perret M, Berland JL, Sodoyer M, Pol S, Bréchot C, Paranhos-Baccalà G, Lotteau V. Characterization of low- and very-low-density hepatitis C virus RNA-containing particles. J Virol. 2002 Jul;76(14):6919-28. Perrin-Cocon L, Coutant F, Agaugué S, Deforges S, André P, Lotteau V. Oxidized low-density lipoprotein promotes mature dendritic cell transition from differentiating monocyte. J Immunol. 2001 Oct 1;167(7):3785-91. Komurian-Pradel F, Paranhos-Baccalà G, Sodoyer M, Chevallier P, Mandrand B, Lotteau V, André P. Quantitation of HCV RNA using real-time PCR and fluorimetry. J Virol Methods. 2001 Jun;95(1-2):111-9. |
Brevets
: |
Methods
for screening compounds for treating and/or preventing an hepatitis C
virus infection. Dépôt 02-2008 Régulation de la réplication du VHC par FXR. Procédés, utilisations et compositions pour moduler la réplication du VHC par activation ou inhibition du récepteur farnesoïde X (FXR). Dépôt 20-08-06 (WO/2008/017692) LIPOCHOL. Utilisation de la alpha-lyso-phosphatidylcholine et composé équivalent pour obtenir la différenciation de monocytes en cellules dendritiques matures. FR02/03499 LDLox. Utilisation de lipoprotéines oxydées pour obtenir la différenciation de monocytes en cellules dendritiques matures. FR01/09103 PARTICULTE. Procédé de culture du VHC consistant à utiliser des cellules capables de synthétiser des lipoprotéines. FR02/07600 HCVCULT. Complexe de lipo-viro-particules, procédé de préparation et applications. FR01/02507 |
Mise
à jour le 29/01/2009 |